The Chicago Cubs (12-9) are set to face off against the Arizona Diamondbacks (12-7) in an exciting National League matchup this Friday. The Cubs enter this game having lost two of their last three encounters, including a 4-2 defeat at the hands of the San Diego Padres on Wednesday. Meanwhile, the Diamondbacks are riding high on a five-game winning streak, having recently completed a series sweep against the Miami Marlins capped off with a 6-4 win on Thursday. Colin Rea (1-0, 1.00 ERA) is slated to pitch for the Cubs, while the mound for the Diamondbacks will be defended by Corbin Burnes (0-1, 5.28 ERA).
The first pitch is scheduled for 2:20 p.m. ET at the iconic Wrigley Field. According to the most recent odds from FanDuel Sportsbook, Arizona is slightly favored at -112 on the money line (a $112 bet could net you $100), with the over/under set at 11.5 runs. Before placing any bets on the Cubs vs. Diamondbacks clash, it’s worth checking the MLB predictions and betting guidance from SportsLine’s trusted computer model.
SportsLine’s Projection Model, which simulates every MLB game 10,000 times, is heating up as it enters Week 4 of the 2025 MLB season with an impressive 8-3 record on MLB money-line bets (+340). This track record promises considerable payouts for those betting in sportsbooks and using betting apps.
Currently, the model has turned its attention to the Diamondbacks vs. Cubs game and locked in its predictions. Some noteworthy MLB odds and betting lines for this match include:
Why the Cubs might succeed
Right fielder Kyle Tucker is a powerful force for the Cubs, ranking fourth in the league with 19 RBI, five home runs, and a batting average of .301. His performance on April 15 against the Padres saw him land 2 of 5, marking his eighth multi-hit game this season.
Second baseman Nico Hoerner is known for his keen eye at the plate, boasting a team-leading .313 average with 11 RBI and 21 hits. On April 14 against San Diego, he delivered a stellar performance going 2-for-4 with a double and a run scored.
Why the Diamondbacks could prevail
Center fielder Corbin Carroll wields a smooth swing capable of sending the ball flying into any gap on the field. Ranked 12th for batting average (.329), tying for fourth in homers (6), and ninth in RBI (16), the 24-year-old enters this game with a 10-game hitting streak. In their April 15 win over Miami, he went 2-for-5, smashing a home run, a double, and driving in five runs.
First baseman Josh Naylor brings additional power to the lineup, hitting .328 with three home runs and 12 RBI. He’s on a roll, hitting a homer in three consecutive games. In the recent win over Arizona, Naylor was 1-for-4 with a solo home run.
Making Diamondbacks vs. Cubs selections
The SportsLine model leans towards an Under play on the total, forecasting a combined 9.1 runs, and suggests that one side of the money line harbors significant value.